WILLIAM S. BUSH, PHD, MS

Associate Director for Bioinformatics Research

William S. Bush, PhD, MS, is Associate Professor in the Department of Population and Quantitative Health Sciences and the Cleveland Institute for Computational Biology at Case Western Reserve University. Dr. Bush received his PhD at Vanderbilt University in Human Genetics in 2008 and then continued as a post-doctoral fellow in the Neurogenomics Training Program at Vanderbilt. Dr. Bush was recently named a Mt. Sinai Health Care Foundation Scholar. As a human geneticist and bioinformatician, Dr. Bush’s research interests include understanding the functional impact of genetic variation, developing statistical and bioinformatics approaches for integrating functional genomics knowledge into genetic analysis, and the use of electronic medical records for translational research.

Affiliations

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Featured Publications

Towards a phenome-wide catalog of human clinical traits impacted by genetic ancestry.

Dumitrescu L, Restrepo NA, Goodloe R, Boston J, Farber-Eger E, Pendergrass SA, Bush WS, Crawford DC,. Racial/ethnic differences for commonly measured clinical variables are well documented, and it has been postulated that population-specific genetic factors may play a role. The genetic heterogeneity of admixed populations, such as African Americans, provides a unique opportunity to identify […]

Gene expression in cell lines from propionic acidemia patients, carrier parents, and controls.

Chapman KA, Bush WS, Zhang Z,. Propionic acidemia (PA) is an inborn of metabolism which usually presents with metabolic acidosis and accumulation of 3-hydroxypropionate among other toxins. Examining the gene expression in lymphoblastoid cell lines (LCLs) from PA patients, their carrier parents and age/sex-matched controls at normal glucose and low glucose growth conditions demonstrated differences […]

Sex-Specific Parental Effects on Offspring Lipid Levels.

Predazzi IM, Sobota RS, Sanna S, Bush WS, Bartlett J, Lilley JS, Linton MF, Schlessinger D, Cucca F, Fazio S, Williams SM,. Plasma lipid levels are highly heritable traits, but known genetic loci can only explain a small portion of their heritability.In this study, we analyzed the role of parental levels of total cholesterol (TC), […]

Recent Publications

  1. Kuzma, A, Valladares, O, Greenfest-Allen, E, Nicaretta, H, Kirsch, M, Ren, Y, Katanic, Z, White, H, Wilk, A, Bass, L et al.. NIAGADS: A data repository for Alzheimer's disease and related dementia genomics. Alzheimers Dement 2025; 21 (6): e70255. PubMed PMID:40545618 PubMed Central PMC12183107.
  2. Eissman, JM, Regelson, AN, Walters, S, Archer, DB, Durant, A, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Trittschuh, EH et al.. Sex-Specific Genetic Drivers of Memory, Executive Functioning, and Language Performance in Older Adults. medRxiv 2025; : . PubMed PMID:40492063 PubMed Central PMC12148254.
  3. Leung, YY, Lee, WP, Kuzma, AB, Nicaretta, H, Valladares, O, Gangadharan, P, Qu, L, Zhao, Y, Ren, Y, Cheng, PL et al.. Alzheimer's Disease Sequencing Project release 4 whole genome sequencing dataset. Alzheimers Dement 2025; 21 (5): e70237. PubMed PMID:40407102 PubMed Central PMC12100500.
  4. Liu, S, Bush, WS, Akinyemi, RO, Byrd, GS, Caban-Holt, AM, Rajabli, F, Reitz, C, Kunkle, BW, Tosto, G, Vance, JM et al.. Alzheimer disease is (sometimes) highly heritable: Drivers of variation in heritability estimates for binary traits, a systematic review. medRxiv 2025; : . PubMed PMID:40343016 PubMed Central PMC12060970.
  5. Lorincz-Comi, N, Yang, Y, Ajayakumar, J, Mews, M, Bermudez, V, Bush, W, Zhu, X. HORNET: tools to find genes with causal evidence and their regulatory networks using eQTLs. Bioinform Adv 2025; 5 (1): vbaf068. PubMed PMID:40270926 PubMed Central PMC12014422.
  6. Griswold, AJ, Rajabli, F, Gu, T, Arvizu, J, Golightly, CG, Whitehead, PL, Hamilton-Nelson, KL, Adams, LD, Sanchez, JJ, Mena, PR et al.. Generalizability of tau and amyloid plasma biomarkers in Alzheimer's disease cohorts of diverse genetic ancestries. Alzheimers Dement 2025; 21 (3): e14367. PubMed PMID:40133765 PubMed Central PMC11936763.
  7. Mews, MA, Naj, AC, Griswold, AJ, Alzheimer's Disease Genetics Consortium, Below, JE, Bush, WS. Brain and blood transcriptome-wide association studies identify five novel genes associated with Alzheimer's disease. J Alzheimers Dis 2025; 105 (1): 228-244. PubMed PMID:40111921 .
  8. Phillips, JM, Dumitrescu, LC, Archer, DB, Regelson, AN, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Trittschuh, EH, Kukull, WA et al.. Novel modelling approaches to elucidate the genetic architecture of resilience to Alzheimer's disease. Brain 2025; : . PubMed PMID:40111762 .
  9. Durant, A, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Klinedinst, BS, Trittschuh, EH, Mez, J, Farrer, LA, Gifford, KA et al.. Evaluating the association of APOE genotype and cognitive resilience in SuperAgers. medRxiv 2025; : . PubMed PMID:39830268 PubMed Central PMC11741496.
  10. Leung, YY, Lee, WP, Kuzma, AB, Nicaretta, H, Valladares, O, Gangadharan, P, Qu, L, Zhao, Y, Ren, Y, Cheng, PL et al.. Alzheimer's Disease Sequencing Project Release 4 Whole Genome Sequencing Dataset. medRxiv 2024; : . PubMed PMID:39677464 PubMed Central PMC11643159.
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