WILLIAM S. BUSH, PHD, MS

Associate Director for Bioinformatics Research

William S. Bush, PhD, MS, is Associate Professor in the Department of Population and Quantitative Health Sciences and the Cleveland Institute for Computational Biology at Case Western Reserve University. Dr. Bush received his PhD at Vanderbilt University in Human Genetics in 2008 and then continued as a post-doctoral fellow in the Neurogenomics Training Program at Vanderbilt. Dr. Bush was recently named a Mt. Sinai Health Care Foundation Scholar. As a human geneticist and bioinformatician, Dr. Bush’s research interests include understanding the functional impact of genetic variation, developing statistical and bioinformatics approaches for integrating functional genomics knowledge into genetic analysis, and the use of electronic medical records for translational research.

Affiliations

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Featured Publications

Towards a phenome-wide catalog of human clinical traits impacted by genetic ancestry.

Dumitrescu L, Restrepo NA, Goodloe R, Boston J, Farber-Eger E, Pendergrass SA, Bush WS, Crawford DC,. Racial/ethnic differences for commonly measured clinical variables are well documented, and it has been postulated that population-specific genetic factors may play a role. The genetic heterogeneity of admixed populations, such as African Americans, provides a unique opportunity to identify […]

Gene expression in cell lines from propionic acidemia patients, carrier parents, and controls.

Chapman KA, Bush WS, Zhang Z,. Propionic acidemia (PA) is an inborn of metabolism which usually presents with metabolic acidosis and accumulation of 3-hydroxypropionate among other toxins. Examining the gene expression in lymphoblastoid cell lines (LCLs) from PA patients, their carrier parents and age/sex-matched controls at normal glucose and low glucose growth conditions demonstrated differences […]

Sex-Specific Parental Effects on Offspring Lipid Levels.

Predazzi IM, Sobota RS, Sanna S, Bush WS, Bartlett J, Lilley JS, Linton MF, Schlessinger D, Cucca F, Fazio S, Williams SM,. Plasma lipid levels are highly heritable traits, but known genetic loci can only explain a small portion of their heritability.In this study, we analyzed the role of parental levels of total cholesterol (TC), […]

Recent Publications

  1. Ray, NR, Kumar, A, Kunkle, BW, Rajabli, F, Bush, WS, Wang, L, Xu, W, Jin, F, Yilmaz, E, Kizil, C et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e107411. PubMed PMID:41447296 PubMed Central PMC12739895.
  2. Benchek, P, Reitz, C, Dietrich, ST, Ray, NR, Hamilton-Nelson, KL, Beecham, GW, Vance, JM, Byrd, GS, Kurup, JT, Tosto, G et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e107285. PubMed PMID:41447272 PubMed Central PMC12739911.
  3. Gulhan, A, Tejeda, M, Newman, C, Farrell, JJ, Zhu, C, Wetzler, L, Lunetta, KL, Bush, WS, Martin, ER, Wang, LS et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e107340. PubMed PMID:41447170 PubMed Central PMC12739684.
  4. Mews, M, Mustafa, Y, Wheeler, NR, Gu, T, Gomez, L, Adams, LD, Starks, TD, Cornejo-Olivas, M, Illanes-Manrique, M, Silva, C et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e106835. PubMed PMID:41447076 PubMed Central PMC12739627.
  5. Martin, ER, Griswold, AJ, Rajabli, F, Gu, T, Golightly, CG, Whitehead, PG, Hamilton-Nelson, KL, Adams, LD, Sanchez, JJ, Rodriguez, VC et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e107001. PubMed PMID:41447028 PubMed Central PMC12739569.
  6. Tejeda, M, Farrell, JJ, Zhu, C, Wetzler, L, Lunetta, KL, Mez, J, Bush, WS, Martin, ER, Wang, LS, Schellenberg, GD et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e106840. PubMed PMID:41446937 PubMed Central PMC12739538.
  7. Wheeler, NR, Hamilton-Nelson, KL, Naj, AC, Reitz, C, Williams, SM, Tosto, G, Byrd, GS, Akinyemi, JO, Adams, LD, Coker, M et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e106790. PubMed PMID:41445535 PubMed Central PMC12739542.
  8. Yang, Y, Bai, H, Benchek, P, Dumitrescu, L, Hohman, TJ, Hamilton-Nelson, KL, Griswold, AJ, Martin, ER, Schellenberg, GD, Mayeux, R et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e106626. PubMed PMID:41445431 PubMed Central PMC12739442.
  9. Mena, PR, Zaman, AF, Cuccaro, ML, McInerney, KF, Adams, LD, Chavez, J, Reitz, C, Tosto, G, Bush, WS, Haines, JL et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e106589. PubMed PMID:41445168 PubMed Central PMC12739226.
  10. Durant, A, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Klinedinst, B, Trittschuh, EH, Mez, J, Farrer, LA, Cruchaga, C et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e106764. PubMed PMID:41444932 PubMed Central PMC12738471.
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