WILLIAM S. BUSH, PHD, MS

Associate Director for Bioinformatics Research

William S. Bush, PhD, MS, is Associate Professor in the Department of Population and Quantitative Health Sciences and the Cleveland Institute for Computational Biology at Case Western Reserve University. Dr. Bush received his PhD at Vanderbilt University in Human Genetics in 2008 and then continued as a post-doctoral fellow in the Neurogenomics Training Program at Vanderbilt. Dr. Bush was recently named a Mt. Sinai Health Care Foundation Scholar. As a human geneticist and bioinformatician, Dr. Bush’s research interests include understanding the functional impact of genetic variation, developing statistical and bioinformatics approaches for integrating functional genomics knowledge into genetic analysis, and the use of electronic medical records for translational research.

Affiliations

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Featured Publications

Antiepileptic activity of preferential inhibitors of persistent sodium current.

Anderson LL, Thompson CH, Hawkins NA, Nath RD, Petersohn AA, Rajamani S, Bush WS, Frankel WN, Vanoye CG, Kearney JA, George AL,. Evidence from basic neurophysiology and molecular genetics has implicated persistent sodium current conducted by voltage-gated sodium (NaV ) channels as a contributor to the pathogenesis of epilepsy. Many antiepileptic drugs target NaV channels […]

eMERGEing progress in genomics-the first seven years.

Crawford DC, Crosslin DR, Tromp G, Kullo IJ, Kuivaniemi H, Hayes MG, Denny JC, Bush WS, Haines JL, Roden DM, McCarty CA, Jarvik GP, Ritchie MD,. The electronic MEdical Records & GEnomics (eMERGE) network was established in 2007 by the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH) in part […]

Automated quantification of pancreatic β-cell mass.

Golson ML, Bush WS, Brissova M,. β-Cell mass is a parameter commonly measured in studies of islet biology and diabetes. However, the rigorous quantification of pancreatic β-cell mass using conventional histological methods is a time-consuming process. Rapidly evolving virtual slide technology with high-resolution slide scanners and newly developed image analysis tools has the potential to […]

Recent Publications

  1. Liu, S, Bush, WS, Akinyemi, RO, Byrd, GS, Caban-Holt, AM, Rajabli, F, Reitz, C, Kunkle, BW, Tosto, G, Vance, JM et al.. Alzheimer disease is (sometimes) highly heritable: Drivers of variation in heritability estimates for binary traits, a systematic review. PLoS Genet 2025; 21 (9): e1011701. PubMed PMID:40906820 PubMed Central PMC12419754.
  2. Osterman, MD, Song, YE, Lynn, A, Miskimen, K, Wheeler, NR, Bartlett, J, Farrer, LA, Schellenberg, GD, Martin, ER, Pericak-Vance, MA et al.. Examining the Performance of Polygenic Risk Scores for Alzheimer Disease Within and Across Populations Using k-Fold Cross-Validation. Neurol Genet 2024; 10 (6): e200198. PubMed PMID:40881139 PubMed Central PMC11727989.
  3. Akinyemi, R, Omotoso, O, Kamada, L, Ndetei, D, Cuccaro, M, Akpalu, A, Adams, LD, Sarfo, SF, Njamnshi, AK, Whitehead, P et al.. Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD-ADSP): A global effort to identify genetic factors in Alzheimer's disease. Alzheimers Dement (N Y) 2025; 11 (3): e70148. PubMed PMID:40861501 PubMed Central PMC12375874.
  4. Akgun, B, Gulyayev, AV, Coker, M, Hamilton-Nelson, KL, Olalusi, O, Adams, LD, Akinwande, K, Whitehead, PG, Diala, S, Ogunronbi, M et al.. ABCA7 deletion lowers age at onset of Alzheimer's disease and interacts with APOE ε4 synergistically in African-ancestry populations. Alzheimers Dement 2025; 21 (8): e70583. PubMed PMID:40832784 PubMed Central PMC12365657.
  5. Cheng, PL, Wang, H, Dombroski, BA, Farrell, JJ, Horng, I, Chung, T, Tosto, G, Kunkle, BW, Bush, WS, Vardarajan, B et al.. A specialized reference panel with structural variants integration for improving genotype imputation in Alzheimer disease and related dementias. HGG Adv 2025; 6 (4): 100487. PubMed PMID:40751311 PubMed Central PMC12362095.
  6. Ciesielski, TH, Tosto, G, Durodoye, RO, Rajabli, F, Akinyemi, RO, Byrd, GS, Bush, WS, Kunkle, BW, Reitz, C, Vance, JM et al.. Country-level incidence of Alzheimer disease and related dementias is associated with increased omega-6-PUFA consumption. Commun Med (Lond) 2025; 5 (1): 326. PubMed PMID:40745374 PubMed Central PMC12314086.
  7. Rajabli, F, Benchek, P, Tosto, G, Kushch, N, Sha, J, Bazemore, K, Zhu, C, Lee, WP, Haut, J, Hamilton-Nelson, KL et al.. Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease. Genome Biol 2025; 26 (1): 210. PubMed PMID:40676597 PubMed Central PMC12273372.
  8. Kuzma, A, Valladares, O, Greenfest-Allen, E, Nicaretta, H, Kirsch, M, Ren, Y, Katanic, Z, White, H, Wilk, A, Bass, L et al.. NIAGADS: A data repository for Alzheimer's disease and related dementia genomics. Alzheimers Dement 2025; 21 (6): e70255. PubMed PMID:40545618 PubMed Central PMC12183107.
  9. Eissman, JM, Regelson, AN, Walters, S, Archer, DB, Durant, A, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Trittschuh, EH et al.. Sex-Specific Genetic Drivers of Memory, Executive Functioning, and Language Performance in Older Adults. medRxiv 2025; : . PubMed PMID:40492063 PubMed Central PMC12148254.
  10. Leung, YY, Lee, WP, Kuzma, AB, Nicaretta, H, Valladares, O, Gangadharan, P, Qu, L, Zhao, Y, Ren, Y, Cheng, PL et al.. Alzheimer's Disease Sequencing Project release 4 whole genome sequencing dataset. Alzheimers Dement 2025; 21 (5): e70237. PubMed PMID:40407102 PubMed Central PMC12100500.
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