WILLIAM S. BUSH, PHD, MS

Associate Director for Bioinformatics Research

William S. Bush, PhD, MS, is Associate Professor in the Department of Population and Quantitative Health Sciences and the Cleveland Institute for Computational Biology at Case Western Reserve University. Dr. Bush received his PhD at Vanderbilt University in Human Genetics in 2008 and then continued as a post-doctoral fellow in the Neurogenomics Training Program at Vanderbilt. Dr. Bush was recently named a Mt. Sinai Health Care Foundation Scholar. As a human geneticist and bioinformatician, Dr. Bush’s research interests include understanding the functional impact of genetic variation, developing statistical and bioinformatics approaches for integrating functional genomics knowledge into genetic analysis, and the use of electronic medical records for translational research.

Affiliations

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Featured Publications

Antiepileptic activity of preferential inhibitors of persistent sodium current.

Anderson LL, Thompson CH, Hawkins NA, Nath RD, Petersohn AA, Rajamani S, Bush WS, Frankel WN, Vanoye CG, Kearney JA, George AL,. Evidence from basic neurophysiology and molecular genetics has implicated persistent sodium current conducted by voltage-gated sodium (NaV ) channels as a contributor to the pathogenesis of epilepsy. Many antiepileptic drugs target NaV channels […]

eMERGEing progress in genomics-the first seven years.

Crawford DC, Crosslin DR, Tromp G, Kullo IJ, Kuivaniemi H, Hayes MG, Denny JC, Bush WS, Haines JL, Roden DM, McCarty CA, Jarvik GP, Ritchie MD,. The electronic MEdical Records & GEnomics (eMERGE) network was established in 2007 by the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH) in part […]

Automated quantification of pancreatic β-cell mass.

Golson ML, Bush WS, Brissova M,. β-Cell mass is a parameter commonly measured in studies of islet biology and diabetes. However, the rigorous quantification of pancreatic β-cell mass using conventional histological methods is a time-consuming process. Rapidly evolving virtual slide technology with high-resolution slide scanners and newly developed image analysis tools has the potential to […]

Recent Publications

  1. Ray, NR, Kumar, A, Kunkle, BW, Rajabli, F, Bush, WS, Wang, L, Xu, W, Jin, F, Yilmaz, E, Kizil, C et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e107411. PubMed PMID:41447296 PubMed Central PMC12739895.
  2. Benchek, P, Reitz, C, Dietrich, ST, Ray, NR, Hamilton-Nelson, KL, Beecham, GW, Vance, JM, Byrd, GS, Kurup, JT, Tosto, G et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e107285. PubMed PMID:41447272 PubMed Central PMC12739911.
  3. Gulhan, A, Tejeda, M, Newman, C, Farrell, JJ, Zhu, C, Wetzler, L, Lunetta, KL, Bush, WS, Martin, ER, Wang, LS et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e107340. PubMed PMID:41447170 PubMed Central PMC12739684.
  4. Mews, M, Mustafa, Y, Wheeler, NR, Gu, T, Gomez, L, Adams, LD, Starks, TD, Cornejo-Olivas, M, Illanes-Manrique, M, Silva, C et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e106835. PubMed PMID:41447076 PubMed Central PMC12739627.
  5. Martin, ER, Griswold, AJ, Rajabli, F, Gu, T, Golightly, CG, Whitehead, PG, Hamilton-Nelson, KL, Adams, LD, Sanchez, JJ, Rodriguez, VC et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e107001. PubMed PMID:41447028 PubMed Central PMC12739569.
  6. Tejeda, M, Farrell, JJ, Zhu, C, Wetzler, L, Lunetta, KL, Mez, J, Bush, WS, Martin, ER, Wang, LS, Schellenberg, GD et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e106840. PubMed PMID:41446937 PubMed Central PMC12739538.
  7. Wheeler, NR, Hamilton-Nelson, KL, Naj, AC, Reitz, C, Williams, SM, Tosto, G, Byrd, GS, Akinyemi, JO, Adams, LD, Coker, M et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e106790. PubMed PMID:41445535 PubMed Central PMC12739542.
  8. Yang, Y, Bai, H, Benchek, P, Dumitrescu, L, Hohman, TJ, Hamilton-Nelson, KL, Griswold, AJ, Martin, ER, Schellenberg, GD, Mayeux, R et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e106626. PubMed PMID:41445431 PubMed Central PMC12739442.
  9. Mena, PR, Zaman, AF, Cuccaro, ML, McInerney, KF, Adams, LD, Chavez, J, Reitz, C, Tosto, G, Bush, WS, Haines, JL et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e106589. PubMed PMID:41445168 PubMed Central PMC12739226.
  10. Durant, A, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Klinedinst, B, Trittschuh, EH, Mez, J, Farrer, LA, Cruchaga, C et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e106764. PubMed PMID:41444932 PubMed Central PMC12738471.
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