WILLIAM S. BUSH, PHD, MS

Associate Director for Bioinformatics Research

William S. Bush, PhD, MS, is Associate Professor in the Department of Population and Quantitative Health Sciences and the Cleveland Institute for Computational Biology at Case Western Reserve University. Dr. Bush received his PhD at Vanderbilt University in Human Genetics in 2008 and then continued as a post-doctoral fellow in the Neurogenomics Training Program at Vanderbilt. Dr. Bush was recently named a Mt. Sinai Health Care Foundation Scholar. As a human geneticist and bioinformatician, Dr. Bush’s research interests include understanding the functional impact of genetic variation, developing statistical and bioinformatics approaches for integrating functional genomics knowledge into genetic analysis, and the use of electronic medical records for translational research.

Affiliations

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Featured Publications

Is Isolated Low High-Density Lipoprotein Cholesterol a Cardiovascular Disease Risk Factor? New Insights From the Framingham Offspring Study.

Bartlett J, Predazzi IM, Williams SM, Bush WS, Kim Y, Havas S, Toth PP, Fazio S, Miller M,. Although the inverse association between high-density lipoprotein cholesterol (HDL-C) and risk of cardiovascular disease (CVD) has been long established, it remains unclear whether low HDL-C remains a CVD risk factor when levels of low-density lipoprotein cholesterol (LDL-C) […]

The phenotypic legacy of admixture between modern humans and Neandertals.

Simonti CN, Vernot B, Bastarache L, Bottinger E, Carrell DS, Chisholm RL, Crosslin DR, Hebbring SJ, Jarvik GP, Kullo IJ, Li R, Pathak J, Ritchie MD, Roden DM, Verma SS, Tromp G, Prato JD, Bush WS, Akey JM, Denny JC, Capra JA,. Many modern human genomes retain DNA inherited from interbreeding with archaic hominins, such […]

Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium.

Hohman TJ, Bush WS, Jiang L, Brown-Gentry KD, Torstenson ES, Dudek SM, Mukherjee S, Naj A, Kunkle BW, Ritchie MD, Martin ER, Schellenberg GD, Mayeux R, Farrer LA, Pericak-Vance MA, Haines JL, Thornton-Wells TA, ,. Late-onset Alzheimer disease (AD) has a complex genetic etiology, involving locus heterogeneity, polygenic inheritance, and gene-gene interactions; however, the investigation […]

Recent Publications

  1. Griswold, AJ, Akinyemi, RO, Rajabli, F, Ayele, BA, Coker, M, Scott, KM, Akinwande, K, Adams, LD, Diala, S, Whitehead, PG et al.. Biomarkers. Alzheimers Dement 2025; 21 Suppl 2 : e105522. PubMed PMID:41503859 .
  2. Song, YE, Wang, P, Laux, RA, Fuzzell, SL, Hochstetler, SD, Miskimen, KL, Lynn, A, Wang, W, Liu, Y, Moore, NC et al.. Biomarkers. Alzheimers Dement 2025; 21 Suppl 2 : e106620. PubMed PMID:41502345 .
  3. Khurshid, Z, Farrell, JJ, Tong, T, Zhu, C, Alzheimer's Disease Sequencing Project, Martin, ER, Bush, W, Pericak-Vance, MA, Wang, LS, Schellenberg, G et al.. Multi-ancestry exome-wide study identifies variants associated with Alzheimer's disease protection. J Alzheimers Dis 2025; : 13872877251405497. PubMed PMID:41428483 .
  4. Ray, NR, Kurup, J, Kumar, A, Rajabli, F, Wang, L, Xu, W, Jin, F, Yilmaz, E, Kizil, C, Bertholim-Nasciben, L et al.. Local genetic correlation analysis of Alzheimer's disease and stroke implicates PHLPP1 as a shared locus in individuals of African ancestry. medRxiv 2025; : . PubMed PMID:41404293 PubMed Central PMC12704622.
  5. Sun, X, Mews, M, Wheeler, NR, Benchek, P, Gu, T, Gomez, L, Ray, N, Reitz, C, Naj, AC, Below, JE et al.. Multi-ancestry Transcriptome-Wide Association Study Reveals Shared and Population-Specific Genetic Effects in Alzheimer's Disease. bioRxiv 2025; : . PubMed PMID:41279621 PubMed Central PMC12637479.
  6. Mustafa, Y, Main, LR, Mews, M, Janve, VA, Hohman, TJ, Haines, JL, Song, YE, Griswold, AJ, Pericak-Vance, MA, Scott, WK et al.. Monocyte inflammation and resilience to Alzheimer's disease: novel genetic risk genes identified by transcriptome-wide association study. Transl Psychiatry 2025; 15 (1): 481. PubMed PMID:41253753 PubMed Central PMC12627486.
  7. Gorski, M, Grunin, M, Herold, JM, Fröhlich, B, Behr, M, Wheeler, N, Bush, WS, Song, YE, Zhu, X, Blanton, SH et al.. Diverse-Ancestry GWAS of Age-Related Macular Degeneration on 16,108 Examined Cases and 18,038 Controls. Invest Ophthalmol Vis Sci 2025; 66 (13): 51. PubMed PMID:41159651 PubMed Central PMC12577769.
  8. Cukier, HN, DeRosa, BA, Coombs, LE, Tang, E, Leyva, DR, Lazzaro, AR, Gu, E, Dykxhoorn, DM, Haines, JL, Pericak-Vance, MA et al.. Generation of two isogenic induced pluripotent stem cell lines derived from a Hispanic individual with Alzheimer's Disease and mosaic for loss of the Y chromosome. Stem Cell Res 2025; 89 : 103851. PubMed PMID:41086611 .
  9. Kurniansyah, N, Tasaki, S, Rehman, H, Zhu, C, Farrell, J, Sherva, R, Hauger, R, Merritt, VC, Panizzon, M, Zhang, R et al.. A multi-ancestry polygenic risk score for Alzheimer disease is associated with cognitive decline, hippocampal atrophy and neuropathological hallmarks in diverse populations. medRxiv 2025; : . PubMed PMID:41040715 PubMed Central PMC12486013.
  10. Bledsoe, X, Wang, TC, Wu, Y, Archer, D, Chen, HH, Naj, A, Bush, WS, Hohman, TJ, Dumitrescu, L, Below, JE et al.. Neuroimaging PheWAS and molecular phenotyping implicate PSMC3 in Alzheimer's Disease. medRxiv 2025; : . PubMed PMID:41001458 PubMed Central PMC12458493.
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