WILLIAM S. BUSH, PHD, MS

Associate Director for Bioinformatics Research

William S. Bush, PhD, MS, is Associate Professor in the Department of Population and Quantitative Health Sciences and the Cleveland Institute for Computational Biology at Case Western Reserve University. Dr. Bush received his PhD at Vanderbilt University in Human Genetics in 2008 and then continued as a post-doctoral fellow in the Neurogenomics Training Program at Vanderbilt. Dr. Bush was recently named a Mt. Sinai Health Care Foundation Scholar. As a human geneticist and bioinformatician, Dr. Bush’s research interests include understanding the functional impact of genetic variation, developing statistical and bioinformatics approaches for integrating functional genomics knowledge into genetic analysis, and the use of electronic medical records for translational research.

Affiliations

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Featured Publications

Is Isolated Low High-Density Lipoprotein Cholesterol a Cardiovascular Disease Risk Factor? New Insights From the Framingham Offspring Study.

Bartlett J, Predazzi IM, Williams SM, Bush WS, Kim Y, Havas S, Toth PP, Fazio S, Miller M,. Although the inverse association between high-density lipoprotein cholesterol (HDL-C) and risk of cardiovascular disease (CVD) has been long established, it remains unclear whether low HDL-C remains a CVD risk factor when levels of low-density lipoprotein cholesterol (LDL-C) […]

The phenotypic legacy of admixture between modern humans and Neandertals.

Simonti CN, Vernot B, Bastarache L, Bottinger E, Carrell DS, Chisholm RL, Crosslin DR, Hebbring SJ, Jarvik GP, Kullo IJ, Li R, Pathak J, Ritchie MD, Roden DM, Verma SS, Tromp G, Prato JD, Bush WS, Akey JM, Denny JC, Capra JA,. Many modern human genomes retain DNA inherited from interbreeding with archaic hominins, such […]

Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium.

Hohman TJ, Bush WS, Jiang L, Brown-Gentry KD, Torstenson ES, Dudek SM, Mukherjee S, Naj A, Kunkle BW, Ritchie MD, Martin ER, Schellenberg GD, Mayeux R, Farrer LA, Pericak-Vance MA, Haines JL, Thornton-Wells TA, ,. Late-onset Alzheimer disease (AD) has a complex genetic etiology, involving locus heterogeneity, polygenic inheritance, and gene-gene interactions; however, the investigation […]

Recent Publications

  1. Ray, NR, Kumar, A, Kunkle, BW, Rajabli, F, Bush, WS, Wang, L, Xu, W, Jin, F, Yilmaz, E, Kizil, C et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e107411. PubMed PMID:41447296 PubMed Central PMC12739895.
  2. Benchek, P, Reitz, C, Dietrich, ST, Ray, NR, Hamilton-Nelson, KL, Beecham, GW, Vance, JM, Byrd, GS, Kurup, JT, Tosto, G et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e107285. PubMed PMID:41447272 PubMed Central PMC12739911.
  3. Gulhan, A, Tejeda, M, Newman, C, Farrell, JJ, Zhu, C, Wetzler, L, Lunetta, KL, Bush, WS, Martin, ER, Wang, LS et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e107340. PubMed PMID:41447170 PubMed Central PMC12739684.
  4. Mews, M, Mustafa, Y, Wheeler, NR, Gu, T, Gomez, L, Adams, LD, Starks, TD, Cornejo-Olivas, M, Illanes-Manrique, M, Silva, C et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e106835. PubMed PMID:41447076 PubMed Central PMC12739627.
  5. Martin, ER, Griswold, AJ, Rajabli, F, Gu, T, Golightly, CG, Whitehead, PG, Hamilton-Nelson, KL, Adams, LD, Sanchez, JJ, Rodriguez, VC et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e107001. PubMed PMID:41447028 PubMed Central PMC12739569.
  6. Tejeda, M, Farrell, JJ, Zhu, C, Wetzler, L, Lunetta, KL, Mez, J, Bush, WS, Martin, ER, Wang, LS, Schellenberg, GD et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e106840. PubMed PMID:41446937 PubMed Central PMC12739538.
  7. Wheeler, NR, Hamilton-Nelson, KL, Naj, AC, Reitz, C, Williams, SM, Tosto, G, Byrd, GS, Akinyemi, JO, Adams, LD, Coker, M et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e106790. PubMed PMID:41445535 PubMed Central PMC12739542.
  8. Yang, Y, Bai, H, Benchek, P, Dumitrescu, L, Hohman, TJ, Hamilton-Nelson, KL, Griswold, AJ, Martin, ER, Schellenberg, GD, Mayeux, R et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e106626. PubMed PMID:41445431 PubMed Central PMC12739442.
  9. Mena, PR, Zaman, AF, Cuccaro, ML, McInerney, KF, Adams, LD, Chavez, J, Reitz, C, Tosto, G, Bush, WS, Haines, JL et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e106589. PubMed PMID:41445168 PubMed Central PMC12739226.
  10. Durant, A, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Klinedinst, B, Trittschuh, EH, Mez, J, Farrer, LA, Cruchaga, C et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e106764. PubMed PMID:41444932 PubMed Central PMC12738471.
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