Most body mass index (BMI) genetic loci have been identified in studies of primarily European ancestries. The effect of these loci in other racial/ethnic groups is less clear. Thus, we aimed to characterize the generalizability of 170 established BMI variants, or their proxies, to diverse US populations and trans-ethnically fine-map 36 BMI loci using a […]
Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,496 cases and 18,190 controls. We identified five new loci for glioblastoma (GBM) at 1p31.3 (rs12752552; P 2.04 10(-9), odds […]
It’s the first day of spring, so you know what that means! It means I haven’t posted since winter! Grant, papers, classes…what can I say? I have been very busy, indeed! But, there’s always time for PSB. Always. If you have read my previous posts, you know all about PSB. For the uninitiated, the Pacific […]
We have now organized two symposia focusing on big data and precision medicine topics with a third one in the works focusing on measuring exposures. In an effort to sustain the dialog initiated by each of these events, we are hosting a blog on this website. This blog will feature short opinion pieces and articles […]
In biomedical research, “precision medicine” is the buzz-word or phrase du jour permeating the latest conference abstracts, manuscripts, and grant proposals. Precision medicine is broadly defined as using a data-driven approach to offer tailored treatments or prevention strategies to patients. The recent popularity of the precision medicine term is likely due to the 2015 White […]
The use of genome-wide (whole genome or exome) sequencing for population-based newborn screening presents an opportunity to detect and treat or prevent many more serious early-onset health conditions than is possible today.The Paediatric Task Team of the Global Alliance for Genomics and Health’s Regulatory and Ethics Working Group reviewed current understanding and concerns regarding the […]
We are well into 2017, and I have yet to post an update on the lab’s accomplishments as of the end of 2016. If you were a human being like the rest of us living in 2016, you probably feel the same as many of us about that year. It was a year very much […]
We have a trio of open faculty positions available here at CWRU. The positions are within the Department of Epidemiology and Biostatistics, with some having the opportunity for an additional appointment in the Institute of Computational Biology: Tenure-Track/Tenured Faculty with Expertise in Biomedical Data Science Tenure-Track/Tenured Faculty Position in Cancer Epidemiology Director of the MPH […]
This year’s American Society of Human Genetics (ASHG) was held—where else?—in Vancouver, Canada! Our northern neighbors invited human geneticists far and wide for five days of presentations, networking, and some scientific fun. Of course, I hardly ever pass up the opportunity to attend this meeting. As I have written before, ASHG is a great place […]
It has been a few months since my last post, so you might be asking, “Girl, what have you been up to lately?” Well, let me tell you…. The fall semester is always crazy busy. Classes begin. Our annual symposium is in full swing. And, the conferences. So many conferences. One unexpected meeting to hit […]
Hi Dana! Testing…