WILLIAM S. BUSH, PHD, MS

Associate Director for Bioinformatics Research

William S. Bush, PhD, MS, is Associate Professor in the Department of Population and Quantitative Health Sciences and the Cleveland Institute for Computational Biology at Case Western Reserve University. Dr. Bush received his PhD at Vanderbilt University in Human Genetics in 2008 and then continued as a post-doctoral fellow in the Neurogenomics Training Program at Vanderbilt. Dr. Bush was recently named a Mt. Sinai Health Care Foundation Scholar. As a human geneticist and bioinformatician, Dr. Bush’s research interests include understanding the functional impact of genetic variation, developing statistical and bioinformatics approaches for integrating functional genomics knowledge into genetic analysis, and the use of electronic medical records for translational research.

Affiliations

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Featured Publications

Genetic analysis of biological pathway data through genomic randomization.

Yaspan BL, Bush WS, Torstenson ES, Ma D, Pericak-Vance MA, Ritchie MD, Sutcliffe JS, Haines JL,. Genome Wide Association Studies (GWAS) are a standard approach for large-scale common variation characterization and for identification of single loci predisposing to disease. However, due to issues of moderate sample sizes and particularly multiple testing correction, many variants of […]

Multivariate analysis of regulatory SNPs: empowering personal genomics by considering cis-epistasis and heterogeneity.

Turner SD, Bush WS,. Understanding how genetic variants impact the regulation and expression of genes is important for forging mechanistic links between variants and phenotypes in personal genomics studies. In this work, we investigate statistical interactions among variants that alter gene expression and identify 79 genes showing highly significant interaction effects consistent with genetic heterogeneity. […]

Genome simulation approaches for synthesizing in silico datasets for human genomics.

Ritchie MD, Bush WS,. Simulated data is a necessary first step in the evaluation of new analytic methods because in simulated data the true effects are known. To successfully develop novel statistical and computational methods for genetic analysis, it is vital to simulate datasets consisting of single nucleotide polymorphisms (SNPs) spread throughout the genome at […]

Visualizing SNP statistics in the context of linkage disequilibrium using LD-Plus.

Bush WS, Dudek SM, Ritchie MD,. Often in human genetic analysis, multiple tables of single nucleotide polymorphism (SNP) statistics are shown alongside a Haploview style correlation plot. Readers are then asked to make inferences that incorporate knowledge across these multiple sets of results. To better facilitate a collective understanding of all available data, we developed […]

Recent Publications

  1. Ray, NR, Kumar, A, Kunkle, BW, Rajabli, F, Bush, WS, Wang, L, Xu, W, Jin, F, Yilmaz, E, Kizil, C et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e107411. PubMed PMID:41447296 PubMed Central PMC12739895.
  2. Benchek, P, Reitz, C, Dietrich, ST, Ray, NR, Hamilton-Nelson, KL, Beecham, GW, Vance, JM, Byrd, GS, Kurup, JT, Tosto, G et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e107285. PubMed PMID:41447272 PubMed Central PMC12739911.
  3. Gulhan, A, Tejeda, M, Newman, C, Farrell, JJ, Zhu, C, Wetzler, L, Lunetta, KL, Bush, WS, Martin, ER, Wang, LS et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e107340. PubMed PMID:41447170 PubMed Central PMC12739684.
  4. Mews, M, Mustafa, Y, Wheeler, NR, Gu, T, Gomez, L, Adams, LD, Starks, TD, Cornejo-Olivas, M, Illanes-Manrique, M, Silva, C et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e106835. PubMed PMID:41447076 PubMed Central PMC12739627.
  5. Martin, ER, Griswold, AJ, Rajabli, F, Gu, T, Golightly, CG, Whitehead, PG, Hamilton-Nelson, KL, Adams, LD, Sanchez, JJ, Rodriguez, VC et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e107001. PubMed PMID:41447028 PubMed Central PMC12739569.
  6. Tejeda, M, Farrell, JJ, Zhu, C, Wetzler, L, Lunetta, KL, Mez, J, Bush, WS, Martin, ER, Wang, LS, Schellenberg, GD et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e106840. PubMed PMID:41446937 PubMed Central PMC12739538.
  7. Wheeler, NR, Hamilton-Nelson, KL, Naj, AC, Reitz, C, Williams, SM, Tosto, G, Byrd, GS, Akinyemi, JO, Adams, LD, Coker, M et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e106790. PubMed PMID:41445535 PubMed Central PMC12739542.
  8. Yang, Y, Bai, H, Benchek, P, Dumitrescu, L, Hohman, TJ, Hamilton-Nelson, KL, Griswold, AJ, Martin, ER, Schellenberg, GD, Mayeux, R et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e106626. PubMed PMID:41445431 PubMed Central PMC12739442.
  9. Mena, PR, Zaman, AF, Cuccaro, ML, McInerney, KF, Adams, LD, Chavez, J, Reitz, C, Tosto, G, Bush, WS, Haines, JL et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e106589. PubMed PMID:41445168 PubMed Central PMC12739226.
  10. Durant, A, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Klinedinst, B, Trittschuh, EH, Mez, J, Farrer, LA, Cruchaga, C et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e106764. PubMed PMID:41444932 PubMed Central PMC12738471.
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